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KMID : 1098420060140050267
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Korean Journal of Medicinal Crop Science
2006 Volume.14 No. 5 p.267 ~ p.272
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Antioxidant Constituents from the Leaves of Cedrela sinensis A. Juss
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Lee Ik-Soo
Wei Chun-hua
Thuong Phuong-Thien
Song Kyung-Sik
Seong Yeon-Hee
Bae Ki-Hwan
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Abstract
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Phytochemical study on the EtOAc fraction from the MeOH extract of the leaves of Cedrela sinensis led to the isolation of five known phenolic compounds (1-5), whose structures were identified as (+)-catechin (1), kaempferol-3-0-{alpha}- L-rhamnopyranoside (2), quercetin (3), quercetin-3-O-{alpha}-L-rhamnopyranoside (4), and quercetin-3-O-{beta}-D-glucopyranoside (5), respectively, by comparing their spectral (uv,;JR,;IH;and;^{13}C-NMR,;and;ESI-MS) and physicochemical data with those reported in the literature. Among the isolated compounds (1-5), compounds 1 and 3-5 exhibited significant DPPH radical scavenging effects with IC{_50} values ranging from 21.3{pm}1.4;to;38.1{pm}3.2 {mu}M as well as superoxide anion radical scavenging effects with IC{_50} values ranging from 9.4{pm}0.7;to;21.2{pm}3.6 {mu}M. Furthermore, compounds 1 and 3-5 also exhibited considerable inhibitory effects on LDL peroxidation induced by either CU^{2+} or AAPH with IC{_50} values ranging from 1.4{pm}0.4;to;11.9{pm}1.4;{mu}M. These results indicated that flavonoids are the major constituents of C. sinensis and considered to be antioxidant principles of this plant.
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KEYWORD
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Cedrela sinensis, Flavonoids, Antioxidant, DPPH, Superoxide, LDL oxidation
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